The Genius Life 24: The Guy Who Became Obese on Purpose | Drew Manning

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The Genius Life 24: The Guy Who Became Obese on Purpose | Drew Manning

Drew Manning is a personal trainer, fitness expert, and the host of The Fit2Fat2Fit Experience podcast. Wanting to better understand the needs and struggles of his overweight clients, Drew decided to walk a mile in their shoes. He became temporarily obese, gaining 75 pounds in just over six months. Then he set out to lose the weight, realizing profound truths about how we lose weight, especially when contending with the modern food supply.

What you'll learn from this episode:

  • How, at eight percent body fat, Drew followed through with a "crazy idea" to gain 75 pounds in six months as a way to empathize with his overweight clients—and two-thirds of adults in the United States.

  • What Drew did to gain those extra pounds and then lose them over the course of another six months.

  • The cheap, unhealthy meals and snacks Drew ate growing up in a family of 11 kids, and what it was like to revisit them with an adult's metabolism.

  • What Drew noticed about his energy level, sleep habits, and the extra effort it took to do everyday things he took for granted on his climb toward obesity.

  • Why Drew is glad he was talked out of living overweight for a year, the health problems he encountered just from six months of approaching obesity, and what he learned about developing an emotional connection to unhealthy food and the willpower required to reject it.

  • And much more!

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

Fit2Fat2Fit: The Unexpected Lessons from Gaining and Losing 75 lbs on Purpose by Drew Manning and Bradley Ryan Pierce

The Fit2Fat2Fit Experience podcast

Fit to Fat to Fit on A&E

Fit to Fat to Fit on Lifetime

Fit2Fat2Fit at Instagram

Fit2Fat2Fit at Facebook

Fit2Fat2Fit at YouTube

Fit2Fat2Fit at Twitter

The Esalen Hot Springs in Big Sur

Burning Man

Super Size Me

A video showing Drew's typical daily diet while gaining weight.

8 Steps to Reversing Diabesity by Mark Hyman, MD

Coffee: Should You Drink It? by Max Lugavere, Facebook

F2F2F Keto Diet with Drew Manning

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

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The Genius Life 23: The Benefits of Going Gluten Free | Nicole "NOBREAD" Cogan

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The Genius Life 23: The Benefits of Going Gluten Free | Nicole "NOBREAD" Cogan

Nicole Cogan is the founder and CEO of NOBREAD, a guide to gluten-free recipes and restaurants with product features, travels, and wellness tips that was inspired by the discovery nine years ago that she is allergic to all things gluten. Nicole demonstrates daily that you don't have to let such an allergy keep you from enjoying everything the world has to offer.

What you'll learn from this episode:

  • How Nicole kept careful track of restaurant meals on a spreadsheet as a personal way to dine out with financial clients on Wall Street without causing a scene when it came time to order—and without getting sick.

  • How this Excel spreadsheet evolved into NOBREAD as a way to help others on a similar path during a time when "gluten-free" wasn't yet a familiar concept in the mainstream.

  • How gluten sneaks into weird places you wouldn't expect—like the vinegar sometimes used to make rice sticky for sushi.

  • How Nicole finally discovered her allergy to gluten after a childhood and young adulthood spent in and out of hospitals.

  • How Nicole recommends you might pinpoint and eliminate gluten and other trouble substances from your diet if you suspect you suffer from an allergy or more severe condition like Celiac disease.

  • And much more!

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

NOBREAD

Nicole at Instagram

Nicole at Twitter

Avra

The Genius Life 13: The Power of Time-Restricted Eating aka Intermittent Fasting | Satchin Panda

House

Celiac Disease: 14 Things You Need to Know by Jessica Migala, Health

Enjoy Life Foods

Nature's Path Honey'd Corn Flakes

Erewhon Natural Foods

Great White Venice

Four Cafe

Moon Juice

Bluestone Lane

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 22: How to Eat and Live Like a Rockstar | Matt Nathanson

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The Genius Life 22: How to Eat and Live Like a Rockstar | Matt Nathanson

Matt Nathanson is a platinum-selling recording artist with a number of hit songs under his belt including Come On Get Higher, Faster, Headphones, and more. His new album, Sings His Sad Heart, is due October 5th. Aside from being a mega musical talent and genuinely good guy, he wields a fierce intellect that you'll experience in this wide-ranging interview.

What you'll learn from this episode:

  • Matt's secret obsession with health and the impact food has on his happiness and creativity.

  • How to cultivate love and empathy for yourself and others and why these two emotions are not just the keys to a better work, but a healthier body.

  • How Matt is raising his daughter to appreciate quality nutrition in all aspects of life (not just food).

  • Why he considers news media to be a form of empty calories.

  • Why eating well on tour is so much easier now than it used to be.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here and use code MAXL20 to save 20 percent off!

Resources from this episode:

Pre-order Matt's new album: Sings His Sad Heart

Matt's website

Matt's music

Matt at Instagram

Matt at Facebook

Matt at Twitter

The Gluten-Free Folk Singer by Matt Rodbard, Food Republic

The Beginner's Guide to Intermittent Fasting by James Clear

Shingles, Mayo Clinic

There But For the Grace of God, Go I, Quote Investigator

A Brief History of USDA Food Guides

Economic Inequality: It's Far Worse Than You Think by Nicholas Fitz, Scientific American

Naval Ravikant: The Angel Philosopher on Investing, Making Decisions, Happiness and the Meaning of Life, The Knowledge Project Episode 18

6 Keys for Narcissists to Change Toward the Higher Self by Preston Ni, Psychology Today

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 21: The Healing Power of... Meat? | Crosby Tailor

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The Genius Life 21: The Healing Power of... Meat? | Crosby Tailor

Crosby Tailor is a low carb dessert chef, wellness expert, and fitness model with an incredible intuition for nutrition, exercise, and self experimentation. He returns to the show (check out his last appearance here) to discuss, dissect, and mythbust current dietary trends including the carnivore diet, veganism, the ketogenic (keto) diet, and fruitarianism.

What you'll learn from this episode:

  • What the carnivore diet is, what research suggests about its health benefits, and my informed guess about why this extreme diet might actually be working.

  • The ins and outs of veganism and how to approach such a diet in a way that minimizes the chances of digestive mishaps.

  • If you need to attain perpetual ketosis for the ketogenic diet to work.

  • Crosby's daily routine that helps him hover around eight percent body fat while maintaining high performance in the gym.

  • How you might determine which diet is right for you.

  • And much more!

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

Tailord Life

Crosby at Instagram

Crosby at Twitter

The Genius Life 12: How to Use Mushrooms for Better Health | Tero Isokauppila

Structure and Function: Heat Shock Proteins and Adaptive Immunity by Babak Javid, Paul A. MacAry, and Paul J. Lehner, The Journal of Immunology

Shawn Baker's Carnivore Diet

Hormesis: 4 Ways Stress Makes You Stronger by Dennis Buckley, Natural Stacks

Mikhaila Peterson: Can The Carnivore Diet Cure Chronic Suffering?, Josh Peck Disclosure

The Evidence for a Vegan Diet by James McWilliams, The Atlantic

Sarcopenia: 10 Keys to Keep Your Muscle Mass Up as You Age, Dr. Axe

The Health Advantage of a Vegan Diet: Exploring the Gut Microbiota Connection by Marian Glick-Bauer and Ming-Chin Yeh, Nutrients

Enzymedica Digest Gold with ATPro, High Potency Enzymes for Optimal Digestive Support

The Ketogenic Diet: A Detailed Beginner's Guide to Keto, Healthline

Hacking Your Sweet Tooth with Crosby Tailor, Bulletproof Radio 355

Next|Health

Bulletproof Coffee

In Vitro Evaluation of Antifungal Activity of Monolaurin Against Candida Albicans Biofilms by Dalia Seleem et al., Peer J

Monolaurin: Benefits, Dosage, and Side Effects, Healthline

Polar Minerals, Premier Research Labs

The Genius Life 7: Why You Probably Need to Eat More Salt | James DiNicolantonio, PharmD

Inside the Strange World of 'Fruitarians,' Who Only Eat Raw Fruit by Emily Marthe, Broadly

trusii H2 (Hydrogen Water)—use code CROSBY for 30 percent off!

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

 

 

 

 

 

 

 

 

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The Genius Life 20: The Hidden Secret To Getting Everything You Want | Craig Clemens

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The Genius Life 20: The Hidden Secret To Getting Everything You Want | Craig Clemens

Craig Clemens is one of the most successful advertising copywriters in the world. He's created videos views by hundreds of millions of people online using a unique form of messaging that we're going to dive into today. He's built many of the most successful consumer brands in the health space and he's even the guy responsible for naming this podcast The Genius Life!

What you'll learn from this episode:

  • Simple ways to supercharge your communication skills and powers of influence regardless of your profession.

  • How to grab attention and ensure your message is heard by your intended audience rather than skipped over in favor of the next convenient distraction.

  • The value of social proof—why it's so important for you to leave ratings and reviews on social media for, say, your favorite podcasters and content creators.

  • How to write an "about me" page that people will actually care about (and how not to write one).

  • A story Craig has never told anyone (not even his parents) about how he really passed his high school English class.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here and use code MAXL20 to save 20 percent off!

Resources from this episode:

Golden Hippo

Craig at Medium

Craig at Instagram

Craig at Twitter

The Genius Life 2: The 1 Hack That Changes Your Life | Sarah Anne Stewart

5 Steps That Took Tai Lopez From Rags To Riches by Brian Rashid, Forbes

Every James Bond Opening Sequence, Ranked by Jeremy Glass, Thrillist

The Dark Knight Rises Opening Scene

The Sam Markowitz Group

Julius Dein at Instagram

Double Your Dating by David DeAngelo

Catch Him and Keep Him by Christian Carter

John Carlton

Yanik Silver

Why it Pays to Be Hungry by Les Brown, Goalcast

Eugene Schwartz's 8 Rules of Great Copywriting, Mindvalley Insights

Getting Everything You Can Out of All You've Got: 21 Ways You Can Out-Think, Out-Perform, and Out-Earn the Competition by Jay Abraham

The Pomodoro Technique: The Acclaimed Time-Management System That Has Transformed How We Work by Francesco Cirillo

Influence: The Psychology of Persuasion by Robert B. Cialdini

The Gary Halbert Letter

Opportunity by Eben Pagan

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

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The Genius Life 19: How to Lose Weight and Get in Shape | Sal Di Stefano

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The Genius Life 19: How to Lose Weight and Get in Shape | Sal Di Stefano

Sal Di Stefano is a co-host of top health and fitness podcast Mind Pump Radio. He's a certified personal trainer and gym owner with more than 20 years of experience helping thousands of clients to lose weight and get in shape.

What you'll learn from this episode:

  • How much protein you really need to grow and maintain lean mass, and the importance of protein consumption timing.

  • Why traditional split routines might not be an efficient use of your time in the gym, and what Sal claims is a much better alternative.

  • How steady state cardio like running on a treadmill can actually cause your body to lose muscle and put on more fat.

  • Fasting as it pertains to weight training.

  • Separating muscle building myths from reality.

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

Sal's Blog

Sal at Facebook

Sal at Instagram

Mind Pump Radio

Mind Pump TV

Free Mind Pump Resources

Recipe: How To Make Bulletproof Coffee, Bulletproof Blog

Cardio Sucks for Fat Loss by Sal Di Stefano

7 Signs and Symptoms You Have Leaky Gut Syndrome by Dr. Axe

A Complete Guide On Prohormones, Consumer Health Digest

IIFYM - Counting Your Macros Is F*CKING Up Your Health! | Nutrition Facts + Advice (Jason Phillips)

Mind Pump Radio Episode 620: Chris Kresser on the Chronic Disease Equation, the Potato Hack for Fat Loss

Resistance Training Exercises: Benefits, Definition & Examples

Mind Pump Radio Episode 497: Reverse Dieting to Speed Up Metabolism (Kimera Quah)

The Myth of Optimal Protein Intake by Sal Di Stefano, Mind Pump

Mind Pump Radio Episode 336: The Benefits Of Fasting

What Are Branched-Chain Amino Acids? by Dr. Mercola

MAPS Split

15 Fitness Tips From 1800s Bodybuilder Eugen Sandow That Are Still Good Today by Jake Rossen, Mental Floss

Why Can't I Gain More Muscle? by  Jeremiah Bair, Mind Pump

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

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The Genius Life 18: How to Have a Better Memory | Jim Kwik

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The Genius Life 18: How to Have a Better Memory | Jim Kwik

Jim Kwik woke up in the hospital after suffering head trauma in kindergarten and thereafter experienced profound learning difficulties to the point that he was called "the boy with the broken brain" by his classmates. He's since dedicated his life to learning any available mental trick to overcome his difficulties, and his passion and expertise in the realm of memory have led to him becoming the go-to instructor for people who want to remember better.

What you'll learn from this episode:

  • How Jim overcame problems with what he calls a horrible memory and problems reading to now reading five books a week.

  • Genetics and biology are only responsible for a third of our memory; two thirds are in our control—and a big part of this is our diet.

  • How Jim stopped being shy and introverted to going on to speak at some of the top conferences around the world.

  • How to easily memorize all ten of the Genius Foods featured in my book so you can head to any supermarket without a shopping list and stock up on all the foods that you need to build your best brain yet.

  • The mechanics of voluntary thought and a framework to enjoy learning, reading, and understanding so you can be more effective in your personal and professional life whether you're a student, performer, executive, or mom trying to remember what to pick up from the grocery store!

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here and use code MAXL20 to save 20 percent off!

Resources from this episode:

Kwik Brain Podcast

Kwik Learning

Jim Kwik’s website

Jim Kwik at Facebook

Jim Kwik at Instagram

Jim Kwik at Twitter

The Power of Positive Thinking by Dr. Norman Vincent Peale

Think and Grow Rich by Napoleon Hill

How to Finish One Book a Week by Jim Kwik, SuperheroYou

"We cannot solve our problems with the same thinking that we used when we created them." -Albert Einstein

The Confidence/Competence Loop by Kevin Eikenberry, Leadership & Learning

Start with Why: How Great Leaders Inspire Everyone to Take Action by Simon Sinek

Berkshire Hathaway Star Followed Warren Buffett's Advice: Read 500 Pages a Day by Kathleen Elkins, CNBC

Will Smith and Jim Kwik Talk Running and Reading

Kwik Brain 012: 3 Hacks For Rapid Reading (How to Reduce Subvocalization)

The Genius Life 10: How to Become a World-Changing Innovator | Melissa Schilling

Can Language Skills Ward Off Alzheimer's? A Nuns' Study by Tiffany Sharples, Time

Brain Tip of the Week: Build A Memory Palace by Jim Kwik, SuperheroYou

The Daniel Plan: 40 Days to a Healthier Life by Rick Warren and Dr. Daniel Amen

"Memory Hacks" Part I: The Baker/baker Paradox by Ryan Nguyen, The Almost Doctor's Channel

Kwik Brain 016: My Morning Routine (How to Jumpstart Your Brain & Day) by Jim Kwik

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

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The Genius Life 17: How to Achieve Massive Success and Real Impact | Tom Bilyeu

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The Genius Life 17: How to Achieve Massive Success and Real Impact | Tom Bilyeu

Tom Bilyeu is the host of the wildly successful Impact Theory, where he interviews some of the highest performers of our time. He also hosts the offshoot shows Relationship Theory, with his lovely wife Lisa, and Health Theory, where he interviews the top minds in health. Tom is also a founder of Quest Nutrition, which experienced 57,000 percent growth within its first three years in spite of Tom having no food industry experience before launch.

What you'll learn from this episode:

  • The mindset and tactics that Tom used to achieve massive success in the health industry—which you can apply to any industry.

  • The only thing that matters in life to Tom (and how he came to discover that it's not money).

  • Why intelligence for many of us (myself included) is context-dependent.

  • Tom's health journey: coming from a morbidly obese family and emerging from a run of yo-yo dieting to ultimately find the eating style that worked for him to become lean and stay that way.

  • How the self-described "dumb and lazy" Tom came to embrace the idea that humans are built for adaptation.

  • And much more!

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

Tom's website

Impact Theory

Relationship Theory

Health Theory

What to Eat to Improve Your Memory | Max Lugavere on Health Theory (One of my favorite interviews!)

Quest Nutrition

Tom Bilyeu at YouTube

Tom Bilyeu at Facebook

Tom Bilyeu at Instagram

Tom Bilyeu at Twitter

The Power of Now: A Guide to Spiritual Enlightenment by Eckhart Tolle

Einstein Wrote Tesla A Letter For His 75th Birthday; Here's What It Said by Luke Miller, Truth Theory

Plasticity of the Human Brain by Dr. Arno Villringer, Max Planck Institute for Human Cognitive and Brain Sciences

10 Solid Reasons Why Yo-Yo Dieting Is Bad for You by Matthew Thorpe, Healthline

Peter Attia

Dominic D'Agostino

What is Hedonic Adaptation and How Can it Turn You Into a Sucka?, Mr. Money Mustache

Impact Theory Comics | It's Coming

Becoming Anti-Fragile With Tom Bilyeu—Genius Network

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 16: The Nutrient That Makes Your Skin and Brain Younger | William Sears, MD

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The Genius Life 16: The Nutrient That Makes Your Skin and Brain Younger | William Sears, MD

Dr. William Sears, MD is a Harvard-trained pediatrician who's written more than 40 best-selling books—including The Baby Book, which has sold more than a million copies—and countless articles on nutrition, parenting, and healthy aging. His most recent book is The Dr. Sears T5 Wellness Plan: Transform Your Mind and Body, Five Changes in Five Weeks.

What you'll learn from this episode:

  • How consuming astaxanthin—a novel antioxidant pigment found in marine animals and algae—helps protect your cells from the inside out, benefiting everything from your skin to your eyes and brain.

  • The different type of omega-3s that are commonly found in the diet.

  • The difference between triglyceride forms of omega-3s versus their phospholipid counterparts found in krill oil and foods like salmon roe.

  • Why you're only as healthy as your cell membranes and how to ensure they possess the important property of fluidity.

  • Where Dr. Sears ranks my book among the 42 he's read about the brain.

  • And much more!

This podcast is sponsored by my friends at Four Sigmatic (check out my interview with founder Tero Isokauppila in episode 12), who make a wide range of coffees, elixirs, and teas using mushrooms like chaga, reishi, lion's mane, and more. Go to foursigmatic.com/max to save 15 percent off of everything!

Resources from this episode:

The Baby Book, Revised Edition: Everything You Need to Know About Your Baby from Birth to Age Two by William Sears, Martha Sears, Robert Sears, and James Sears

The Dr. Sears T5 Wellness Plan: Transform Your Mind and Body, Five Changes in Five Weeks by William Sears and Erin Sears Basile

Ask Dr. Sears

The Dr. Sears Wellness Institute

Dr. Sears at Facebook

Dr. Sears at Instagram

Dr. Sears at YouTube

Dr. Sears at Twitter

All About Astaxanthin, Dr. Sears Wellness Institute

Nutrex

Natural Astaxanthin: Hawaii's Supernutrient by William Sears

Wild Salmon vs. Farmed Salmon (from my Instagram page)

12 Frequently Asked Questions About the Vegetarian Diet, Ask Dr. Sears

What You Should Know About Fatty Acids, Dr. Mercola

Health Benefits of Docosahexaenoic Acid (DHA) by L.A. Horrocks and Y.K. Yeo, Pharmacological Research

DHA with Michael Crawford (Video), The Mother and Child Foundation

Health Benefits of Omega-3, Dr. Sears Wellness Institute

Vital Choice Wild Alaskan Sockeye Salmon Oil, Omega-3

Testa Vegan Algae Oil, Omega-3

Health Benefits of Antioxidants, Dr. Sears Wellness Institute

Cell Membrane Fluidity (Video), Khan Academy

The Omega-3 Effect: Everything You Need to Know about the Supernutrient for Living Longer, Happier, and Healthier by James Sears, Bill Lands, and William Sears

Benefits vs. Risks of Omega-6 Fatty Acids, Dr. Axe

How to Optimize Your Omega-6 to Omega-3 Ratio, Healthline

Diet and Lifestyle Change Gave Dr. Sears Renewed Health by Linda Arrandt, Simple + Well

The Official Site for PAC-MAN

Clean 15 vs. Dirty Dozen, Environmental Working Group

Unlocking the Secrets of the Microbiome by Jane E. Brody, The New York Times

NDD (Nutrition Deficit Disorder), Ask Dr. Sears

Louis J. Ignarro, The Nobel Prize in Physiology or Medicine 1998

Endothelial Pharmacy (Video), Dr. Sears Wellness Institute

5 Health Benefits of Nitric Oxide Supplements, Healthline

Vascular Endothelial Growth Factor (VEGF), Health Encyclopedia, University of Rochester Medical Center

8 Ways to Increase BDNF and Keep Your Brain from Aging, Bulletproof

The Scoop on Comfortable Poop by Dr Poo, Ask Dr. Sears (Free Ebook)

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

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The Genius Life 15: Healing Traumatic Brain Injury with Food | Cavin Balaster

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The Genius Life 15: Healing Traumatic Brain Injury with Food | Cavin Balaster

Cavin Balaster suffered a traumatic brain injury (TBI) seven years ago that led to a diffuse axonal injury (DAI), putting him in a coma with a less than 10 percent chance of recovery beyond a persistent vegetative state. But he woke up and recovered in a remarkable way: claiming to owe much of his success to the power of food. He is the author of How to Feed a Brain: Nutrition for Optimal Brain Function and Repair, which is the culmination of the nutritional tools he learned through this journey, and host of The Adventures in Brain Injury Podcast, where he interviews doctors, practitioners, researchers, and others involved in neurorehabilitation and brain function.

What you'll learn from this episode:

  • What it's like to live through a severe traumatic brain injury, and what lies on the long road to rehabilitation.

  • What intestinal permeability is and how gut health played a crucial role in Cavin's recovery.

  • How Cavin now works with the medical teams of TBI sufferers to modify their diets in accordance with his research.

  • The role that fish oil played in Cavin's recovery and how it helps brain health in general.

  • The benefits of the ketogenic diet for someone recovering from a traumatic brain injury.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

Resources from this episode:

How to Feed a Brain: Nutrition for Optimal Brain Function and Repair by Cavin Balaster

The Adventures in Brain Injury Podcast

FeedaBrain.com

Cavin at Instagram

Cavin at Twitter

Traumatic Brain Injury (TBI), Johns Hopkins Medicine

Understanding Diffuse Axonal Injury, Brainline

The Truth About Hospital Food, Plus What to Eat at the Hospital, Dr. Axe

Dr. Thomas Culleton

7 Signs and Symptoms You Have Leaky Gut Syndrome, Dr. Axe

Dr. Datis Kharrazian

All Health Begins in Your Gut! by Cavin Balaster, FeedaBrain.com

What Is the Anti-inflammatory Protocol and What Is It Used For? by Joy Y. Kiddie, BetterByDesign Nutrition

Kettle & Fire Bone Broth

9 Ways to Boost Glutathione, Dr. Axe

DHA and Your Brain by Monica Reinagel, Scientific American

Keith Norris at Paleo f(x)

Omega-3s and Traumatic Brain Injury Treatment by Cavin Balaster, FeedaBrain.com

Ketogenic Diet Benefits by Cavin Balaster, FeedaBrain.com

Coursera

What is Homeostasis?, Scientific American

Primal Fat Burner, Paleo or Ketogenic? Clarifying the Similarities and Differences by Nora Gedgaudas, Primal Body, Primal Mind

Snowboarder Kevin Pearce on Olympic Brain Injuries and the Benefits of Yoga by Maggie Parker, Paste

Love Your Brain

The Crash Reel

The Ghost in My Brain: How a Concussion Stole My Life and How the New Science of Brain Plasticity Helped Me Get it Back by Clark Elliott

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 14: How to Heal Trauma, Fix Back Pain, and Poop Better | Aaron Alexander

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The Genius Life 14: How to Heal Trauma, Fix Back Pain, and Poop Better | Aaron Alexander

Aaron Alexander is an accomplished manual therapist and movement coach with over 13 years of professional experience. He is the founder of the Align Movement, an integrated approach to functional movement and self-care that has helped thousands of people out of pain and into health. He also hosts the top-rated Align Podcast featuring the biggest names in movement and wellness.

What I discuss with Aaron in this episode:

  • Why we shouldn't so easily dismiss our own instincts when technology disagrees with how we feel.

  • The dangers of doing Kegel (or really any) exercises in the wrong position and how we can ensure we're properly poised to reap their rewards.

  • The numerous benefits of human contact once it's unwrapped from the societal hangups that equate it with sex.

  • Common complaints of people in search of body work and potentially physiological origins of anxiety.

  • The biological consequences of carrying feelings of guilt, hate, and anger.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

On this episode of the show, Align Podcast host Aaron Alexander and I talk about everything from the mingling worlds of technology, health, and wellness to movement—particularly why so many people are having knee and lower back problems (including me)—to digestive health to touching and why so many of us are starving for oxytocin.

There's a Nap for That

Kicking off our conversation, Aaron wins the hearts of naturists worldwide when he says fewer clothes correlate to greater health and that he personally tends to feel better when he spends more time (and with more skin) exposed to the sun. Meanwhile, I'm told by certain members of my audience that I need to assemble a less revealing wardrobe if I want to be taken more seriously. So it goes.

While Aaron admits that hormone levels and other labile biomarkers associated with "better" might not be quantifiable without further technical scrutiny, there are drawbacks to relying too much on technology for feedback about what our instincts are already trying to tell us.

"I think having those time slices and having some sort of structure and awareness and being able to check back at what you're doing through periods of change is important," says Aaron. "I think it's also really important to be able to just introspect and look in and be flexing that muscle—and really looking into how do you actually feel as opposed to always looking at your ring on your finger or your necklace or whatever to determine if you feel okay."

We look to apps to tell us how we'll we've slept when maybe we should be looking toward naps if we're feeling drowsier than usual. An app could be spitting out virtual miles of incorrect data if it's in need of an update or some other unknown variable enters the picture. The worst thing a nap is liable to do is make you miss a few hours of questionable daytime television.

Where the Sun Don't (Usually) Shine

Naturists will be further encouraged by Tao of Sexology author Dr. Stephen Thomas Chang's advice to regularly expose the perineum to the sun, but Aaron has some practical advice for those of us who want to maintain this more delicate part of the anatomy without the risk of scorching.

"You can be strengthening and balancing that space—that pelvic floor—just with the way that we're sitting," says Aaron. "Oftentimes we end up being folded over in hunched over positions that end up putting our pelvic floors in a state of compensation, and those muscles are crucially important. It's the foundation of our visceral system—the foundation of our organs."

Being able to contract and engage these muscles keeps our organs functioning properly, allows us to use the restroom on our own timetable, and gives us greater control over sexual function. Enlightened men and women may already be familiar with the benefits of Kegel exercises in strengthening the pelvic floor, but Aaron stresses the importance of proper posture when engaging in them.

"Kegel exercises can actually be deleterious for you if you're in a compromised position," Aaron says.

For instance, if you're on your morning commute and hunched over the steering wheel of your car, or sitting at your computer reading these podcast show notes, doing Kegel exercises can actually strengthen this dysfunctional position. Aaron recommends yoga postures—like sukhasana (easy) or padmasana (full lotus)—as great ways to ensure we're properly aligned before engaging in these exercises.

"Just sitting down, people can pull their butt cheeks back and get yourself on the front edge of your sit bones—the ischial tuberosities—and then from there you'll feel your lower back and your whole spine starts to be able to stack on top of your pelvis," Aaron says. "From that position, now you're safe to do any kind of Kegel."

Similarly, deep squats help increase range of motion and pressure regulation.

The Stigma Behind Human Contact

The health benefits of regular human contact are numerous, but often swept under the rug by societal hangups tying such contact to sex. Being hugged and supported or using massage to work the pain out of trouble areas shouldn't automatically signify lascivious intent.

"When people end up having pain in a certain part of their body, they literally create disassociation around that part," says Aaron. "So they have trouble being able to visualize that place. They won't be able to draw a picture of the place in their body that they have pain because they create a separation. So that disassociation—that's a lot like what we do with emotional trauma…'That was super painful; I don't think I have the tools to address that. Let's just chop it out.' But you didn't chop it out. It's still there. You're just carrying it as baggage. And it slowly accrues—accumulates...until at some point, you pop."

Listen to this full episode to learn more about how Aaron feels about solar-powered testosterone generation, the permanent damage Aaron suffered by bodybuilding to cope with trauma as a teenager, becoming aware of patterns we've each exhibited, what it's like to bond in a desert sweat lodge, the importance of challenging our own narratives, the most common complaints of people seeking body work, the potentially physiological origins of anxiety a lot of us experience, hot yoga versus meditation, the baggage we carry when we can't forgive, how labels only serve to separate and disconnect us, religion as spiritual scaffolding, the silent epidemic of modern lower back pain, ways we can overcome gluteal amnesia and other dysfunctional positions we acquire over time, and lots more.

Resources from this episode:

Align Therapy

Align Podcast

Aaron at Facebook

Aaron at Instagram

Aaron at YouTube

Aaron at Twitter

Align Podcast 161: Max Lugavere II: Genius Foods, Power Language, Nutritional Psychiatry (My appearance on Aaron's podcast)

How do you say labile?

The Tao of Sexology: The Book of Infinite Wisdom by Stephen Thomas Chang

Kegel Exercises: Benefits, Goals, and Cautions, Healthline

How to Do the Yoga Easy Posture (Sukhasana) by Larry Payne and Georg Feuerstein, Yoga for Dummies

How to Do the Yoga Full Lotus Posture (Padmasana) Correctly by Doug Swenson and David Swenson, Power Yoga for Dummies

Massage: Get in Touch with Its Many Benefits, Mayo Clinic

In the Realm of Hungry Ghosts: Close Encounters with Addiction by Gabor Mate

Onnit

After Sweat Lodge Deaths, Fewer Tourists with Spiritual Needs by Marc Lacey, The New Yorker

Plantar Fasciitis Symptoms and Causes, Mayo Clinic

The Brain-Gut Connection, Johns Hopkins Medicine

Why Do People Even Like Hot Yoga? by Amy Marturana, Self

12 Ways to Be Happier

Dr. John Demartini

Alan Watts

Jiddu Krishnamurti

One Love by Bob Marley

When to Worry about Low Back Pain—and When Not To! What's Bark and What's Bite? by Paul Ingraham, PainScience.com

Ancient Ruins of Tiwanacu and PumaPunku, World Mysteries Blog

Get Stronger By Greasing the Groove by Brett McKay, The Art of Manliness

What is Gluteal Amnesia? by Cathe Friedrich

Your Body Language May Shape Who You Are by Amy Cuddy, TED Talk

5 Blue Zones Where People Live the Longest, Healthiest Lives by Jamie Ducharme, Time

Physics of Poo: Why It Takes You and an Elephant the Same Amount of Time by David Hu and Patricia Yang, The Conversation

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 13: The Power of Time-Restricted Eating aka Intermittent Fasting | Satchin Panda

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The Genius Life 13: The Power of Time-Restricted Eating aka Intermittent Fasting | Satchin Panda

Satchin Panda is a professor in the Regulatory Biology Laboratory—aka Panda Lab—at the Salk Institute for Biological Studies in La Jolla, California. His research concerns understanding the molecular mechanism of the biological clock and the part it plays in overall health, as detailed in his book The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight.

What you'll learn from this episode:

  • Dr. Panda's research supports what intermittent fasting proponents have been saying for years: when we eat may be every bit as important to our well-being as what we eat.

  • The negative effects on our health we risk by not sleeping enough, and how we can live a lifestyle that supports ideal, genetically governed circadian rhythms for optimal wellness.

  • The practical implications of time-restricted feeding and why it may be smarter to skew your feeding window earlier in the day.

  • What could explain a recent food hangover I had recently the morning after consuming a late meal.

  • The potential benefits of exercising at a moderate intensity before eating in the morning.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

Resources from this episode:

The Circadian Code: Lose Weight, Supercharge Your Energy, and Transform Your Health from Morning to Midnight by Satchin Panda

Panda Lab

Satchin at Twitter

myCircadianClock App

Diurnal Transcriptome Atlas of a Primate Across Major Neural and Peripheral Tissues

by S. Panda et al., Science

Salk Institute Honored with Historic Gift from Family of the Late Francis Crick, Salk News

Simulated Night Shift Work Induces Circadian Misalignment of the Human Peripheral Blood Mononuclear Cell Transcriptome by Laura Kervezee et al., Proceedings of the National Academy of Sciences

The Emerging Roles of Melanopsin in Behavioral Adaptation to Light by Megumi Hatori and Satchidananda Panda, Trends in Molecular Medicine

Q&A: Why Is Blue Light before Bedtime Bad for Sleep? by Jessica Schmerler, Scientific American

Fasting, Circadian Rhythms, and Time Restricted Feeding in Healthy Lifespan by Valter D. Longo and Satchidananda Panda, Cell Metabolism

A 12-Hour Window for a Healthy Weight by Gretchen Reynolds, The New York Times Magazine

National Sleep Foundation's Updated Sleep Duration Recommendations: Final Report by Max Hirshkowitz et al., Sleep Health

Meal Timing by Rebecca Shern, Minimal Wellness

A Comprehensive Beginner's Guide to the Ketogenic Diet, Ruled.Me

High Carbohydrate Diets and Alzheimer’s Disease by Samuel T. Henderson, Medical Hypotheses

7 Ways a Keto Diet Is Perfect for Menopause by Anna Cabeca, Dr. Axe

Exercise Before Breakfast 'is Better than after a Meal,' Finds Study by Hilary Duncanson, The Independent

How to Break Your Daily Caffeine Habit and Use Coffee Strategically by Kevin Purdy, Fast Company

Circadian Variation in Gastric Vagal Afferent Mechanosensitivity by Amanda J. Page et al., Journal of Neuroscience

Ghrelin: Much More than a Hunger Hormone by Geetali Pradhan et al., Current Opinion in Clinical Nutrition & Metabolic Care

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor by Xuecai Ge at al., Cell Metabolism

The Role of Leptin and Ghrelin in the Regulation of Food Intake and Body Weight in Humans: A Review by MD Klok et al., Obesity Reviews

Time-Restricted Feeding Study Shows Promise in Helping People Shed Body Fat by Adam Pope, University of Alabama at Birmingham News

The Case for a Breakfast Feast by Roni Caryn Rabin, The New York Times

Effects of Caffeine on the Human Circadian Clock in Vivo and in Vitro by Kenneth P. Wright Jr. et al., Science Translational Medicine

NFL Teams Play Better at Night, Study Suggests, Because Of Circadian Rhythms by Ben Renner, StudyFinds

Seasonal Variations in Serum Vitamin D According to Age and Sex by Behzad Heidari and Maryam Beygom Haji Mirghassemi, Caspian Journal of Internal Medicine

Another Case Against the Midnight Snack, Salk News

Frequent Extreme Cold Exposure and Brown Fat and Cold-Induced Thermogenesis: A Study in a Monozygotic Twin by Maarten J. Vosselman et al., PLOS One

Cold Exposure as a Potential Therapy for Type 2 Diabetes, Medical News Bulletin

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 12: How to Use Mushrooms for Better Health | Tero Isokauppila

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The Genius Life 12: How to Use Mushrooms for Better Health | Tero Isokauppila

Tero Isokauppila is a Finnish foraging expert, self-experimenter, founder of medicinal mushroom company Four Sigmatic, and one of the smartest cacao experts I know. He is also the author of Healing Mushrooms: A Practical and Culinary Guide to Using Mushrooms for Whole Body Health.

What I discuss with Tero in this episode:

  • Mushrooms have been used for culinary and medicinal purposes for centuries, and there are likely thousands of undiscovered species that could provide us with yet-untold benefits.

  • Tero Isokauppila didn't start medicinal mushroom company Four Sigmatic as a fad -- he comes from a multi-generational line of mushroom foragers. He's got fungi in his blood!

  • The three criteria of adaptogens and how they were discovered by the Cold War era Soviet Union looking for an edge in optimizing human performance.

  • The mysterious properties of not-quite-plant, not-quite-animal fungi.

  • Why coffee and chocolate work well in combination with mushrooms.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

I've been a fan of mushrooms my whole life—from big portobellos that my family and I would throw on the grill every summer drenched in salt, pepper, and extra virgin olive oil to the raw, sliced mushrooms I drop into a salad. They have a flavor and texture that are at once highly amenable to whatever they're being eaten with, but also retain a delectable taste all their own.

The research on the health benefits of mushrooms is just as compelling. Mushrooms are the fruiting bodies of a large family of organisms from the fungi kingdom, distinct from the animal and plant kingdoms but just as wide and diverse. In fact, there are 22,000 mushroom species that we know of, but it's estimated there are likely 140,000 distinct species on Earth. Of the known mushrooms, about five percent are of either culinary or medicinal use to humans, but if that proportion holds true for the vast number of unexplored mushrooms, this implies there are 6,000 mushrooms out there that could provide us with yet-untold benefits.

On this episode of the show, I'm joined by someone who knows a lot about the medicinal power of mushrooms: Four Sigmatic founder Tero Isokauppila, author of Healing Mushrooms: A Practical and Culinary Guide to Using Mushrooms for Whole Body Health.

Why Mushrooms?

Four Sigmatic (discount code MAX gets you 15% off!) is well-known for making mushroom coffee, mushroom tea, mushroom superfood blends, mushroom hot cacao, and even mushroom lemonade with charcoal and chaga. Which might lead some less enamored of such fungal splendor to wonder: what's the obsession with mushrooms?

"I first fell in love with normal, good old culinary mushrooms," says Tero. "I grew up in Finland. My mom took me out foraging. My mom taught physiology and anatomy and taught me about nutrition in general. [We've had] a family farm for quite a few generations, and my great-great grandfather started an environmental school where we also forage for mushrooms.

"As I was playing soccer and running, I got into all kinds of performance-boosting things beyond just your classic creatine and whey protein that worked, but I wondered 'What's the next level? And the next next level? And the next, next, next level!' And I discovered this mushroom called cordyceps that is shown to improve the maximum oxygen intake, and there's also pretty fascinating studies on ATP production that it can improve 18 percent or more of just how we produce energy in our cells and the mitochondria, so that got me deeper into the world of medicinal mushrooms."

Other benefits of cordyceps include fatigue reduction and up to 10 percent increase in lactic acid threshold in the body—especially helpful during high-intensity workouts. Cordyceps are also the only fungi in a category of herbs known as adaptogens.

What Are Adaptogens and Beta-Glucans?

"Adaptogens" is a word that gets thrown around a lot on the herbal medicine market today, but Tero defines them by these three criteria:

  1. They are safe and non-addictive.

  2. They are non-specific—meaning they'll work in multiple parts of the body.

  3. They have the ability to modulate—that is, they'll help normalize bodily parameters against pathological conditions.

In the 1940s, the Soviet Union became the first nation to understand the role adaptogens can play in stress reduction thanks to the work of Dr. Nikolai Vasilievich Lazarev. While adaptogens may not have helped the Soviets win the Cold War, they're a great way to bolster the body's own ability to heal.

Beta-Glucans are immunity-boosting complex carbohydrates that are found in many bacteria, plants, and fungi—reishi being one reliable source.

"Most of the research is around cancer, autoimmune [diseases], and diabetes," says Tero, "because those are the big problems in our society. But I think just for general health, I look at them like chlorophyll. You want to have greens in some form every day. You want to have polysaccharides in one form or the other every day. You don't need a lot—it's a really important building block and something our body's very quick to handle."

Culinary and Medicinal Mushrooms

Not quite plant and not quite animal, mushrooms occupy a pretty unique place in the biosphere. Sometimes even scientists can't help but wax poetic on their qualities, as we see from the opening to this paper from Shu Ting Chang and Solomon P. Wasser in the International Journal of Medicinal Mushrooms:

"Mushrooms are part of fungal biota characterized by wonder. They rise up from lignocellulosic wastes: yet they become so bountiful and nourishing. Mushrooms are environmentally friendly. They biosynthesize their own food from agricultural crop residues, which would otherwise cause health hazards."

When was the last time you saw a scientist use the phrase "characterized by wonder" in a paper? I can't help but think Amber Rae would approve.

While fungi are less studied than the other kingdoms, it's understandable: they're bountiful almost beyond comprehension. "If you think of all the varieties of plants," says Tero, "there's six times more fungi than there are plants."

While some mushrooms overlap the boundary between culinary and medicinal categories, it's helpful to know the difference.

"Culinary mushrooms are good for fiber, some level of iron, copper, potassium, B vitamins, D vitamins -- pretty much the only non-animal based source of vitamin D is in mushrooms because they share a lot of the DNA with animals, so they have the same way of getting it from the sun. So mushrooms build vitamin D in their skin the same way humans do.

"Medicinal mushrooms have a lot of those same properties, but they also have this intelligence—ninja skills—very specific compounds that can potentially help penetrate the blood-brain barrier or they could help ATP production. They could help improve the gut biome. They have these stronger skills. They tend to be more bitter; they tend to grow on trees, whereas culinary mushrooms tend to grow on the ground. A lot of the benefits of the medicinal mushrooms come from the trees themselves."

Give your ears a listen to this entire episode to learn more about Tero's top seven mushrooms, why Otzi the Iceman (the well-preserved mummy of a man who was murdered 5,300 years ago) was probably carrying medicinal mushrooms at the time of his death, why coffee and chocolate are ideal candidates to combine with mushrooms, fungi Tero recommends avoiding, why Tero prefers wild mushrooms over cultivated mushrooms, and much more.

Resources from this episode:

Tero's website

Four Sigmatic (15% off discount code automatically applied!)

Healing Mushrooms: A Practical and Culinary Guide to Using Mushrooms for Whole Body Health by Tero Isokauppila and Four Sigmatic

Mushroom Academy

Facebook 'Shroom Club

Tero at Instagram

The Genius Life 4: Fat Loss and Inflammation Hacks | Crosby Tailor

The Green Dawn of Adaptogens: Performance Herbs from Back in the USSR, Supplements in Review

Effects of Beta-Glucans on the Immune System by Dalia Akramiene et al., Medicina

The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health by Shu Ting Chang and Solomon P. Wasser, International Journal of Medicinal Mushrooms

The Genius Life 11: How to Quiet the Inner Critic and Experience More Wonder | Amber Rae

The Maitake Mushroom: A Powerful and Promising Medicinal, Mushroom Appreciation

5 Surprising Facts About Otzi the Iceman by James Owen, National Geographic

Medicinal Mushrooms: Ancient Remedies Meet Modern Science by Paul Stamets and Heather Zwickey, Integrative Medicine: A Clinician's Journal

How to Make a Decoction, WikiHow

Guide to Making Tinctures, Mountain Rose Herbs

The Ghrelin Gremlin, or Why You Can’t Always Trust the Body’s Wisdom by Kelly McGonigal, Psychology Today

What Is Candida and What Does It Have to Do with Toxic Mold Exposure?, Surviving Toxic Mold

Mushrooms Are Full of Antioxidants That May Have Anti-Aging Potential by Matt Swayne, Penn State

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 11: How to Quiet the Inner Critic and Experience More Wonder | Amber Rae

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The Genius Life 11: How to Quiet the Inner Critic and Experience More Wonder | Amber Rae

Amber Rae is is an author, artist, and speaker who has been described by mindbodygreen as "The Brené Brown of wonder." Her new book is Choose Wonder Over Worry: Move Beyond Fear and Doubt to Unlock Your Full Potential, and I personally think it would look beautiful on your coffee table after you've absorbed its life-changing insights.

What I discuss with Amber in this episode:

  • How we can use wonder rather than fear as a guide to extract what worry is trying to tell us.

  • The three steps for pushing past fear.

  • Amber's method for conversing with the many faces of worry.

  • Why Amber's process for writing a book may widely differ from that of most other authors.

  • How we can change our own narratives to overwrite the negative conditioning of external forces—like the advertising industry that preys on our sense of "not enough."

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

As human beings, we second guess ourselves constantly. Whether we're creators exposing our chosen form of expression to criticism from the world at large or accountants quadruple-checking receipts for missed deductions at tax time, self-doubt just seems to be part of our DNA. Unexamined, this self-doubt amounts to worrying that stifles us from doing our best work and living our best lives.

But what if worry exists for a reason? What might we learn from it if we dig deeper and let wonder, rather than fear, be our guide? Choose Wonder Over Worry: Move Beyond Fear and Doubt to Unlock Your Full Potential author Amber Ray introduces us to the many faces this worry wears and helps us understand how to confront them constructively and make use of what they're trying to tell us—without being dissuaded from what we really want to accomplish in life.

Worry vs. Wonder

It's no secret that growth to any degree comes from stepping outside whatever we perceive as the comfort zone, and the biggest obstacle to taking this step usually comes from within—in the form of worrying. Everybody knows what it's like to ponder getting better acquainted with the unfamiliar only to hear the nagging voice in the back of our head warning us of what awaits if we fail.

The initial voice of curiosity urging us to ponder the possible is what Amber calls wonder. The inner-ruminating, anxious, and fearful voice begging us to reconsider is worry.

"I remember I walked into an art gallery in lower Manhattan," says Amber. "And when I looked at the mixed media art lining the walls, there was this voice inside of me that said, "It's time to make some art." That was wonder. And then very quickly, another voice said, "Art? Who the hell are you to make art? You didn't go to art school! Like, are you kidding yourself? Come on. Art doesn't make money.

"And you know it took me a while to realize that because often we think, okay, worry is bad, fear's bad, let's make it go away. But that's actually not the aim. It's how do we have a relationship with it? And so what I realized later was that worry, even in that art gallery, was trying to protect me and keep me safe. That seemed unknown, scary, dangerous, unlikely to lead to me being a thriving human, and so worry was chiming in to say, 'Hey! Alert! Danger! I don't know how I feel about this!' But the invitation is that we get to know the two voices and we learn how to work with them and have a relationship with these various internal emotions."

Three Steps for Initiating a Relationship with Worry

"[Worry and fear] are here to keep us safe," says Amber. "We've evolved with them in our brain to protect us from danger. But any time we're doing something new, novel, meaningful, interesting—something that is unknown—it's going to trigger some of those emotional sensations or those voices."

Having a relationship with these emotions rather than letting them boss us around is key—but where do we begin? Amber recommends these three steps.

  1. Name it. Psychotherapist Dr. Dan Siegel coined the term name it to tame it, and that's what Amber considers the first step. It's specifying what kind of worry has shown up and giving it a label to pinpoint the problem it's trying to solve. In herself, Amber identified 27 different kinds of worry, including The Perfectionist, Envy, Shame, and Not Enoughness. Amber jokes that her friend calls this "Multiples of Personality Order."

  2. Talk to it. Amber demonstrates: "As I was writing this book, so many times The Perfectionist would come up and be like, 'Hey, this isn't very good. People aren't going to like this. People are going to judge you.' And I would then talk to that voice. I'd say, 'Okay. Hey, Perfectionist. I see you hanging out here. What is it that you want me to know?' And The Perfectionist would be like, 'Well, you know, I just want this to be really good. And I want a really high-quality end product.' And I'm like, 'Great! Me, too.
    We have the same goal! Amazing!"

  3. Make a request. This is the part where you recognize the validity of what the named worry is trying to tell you, and you politely request that it buzzes off to let you solve the problem. Here's how Amber might make such a request: "'I need to get really messy and create a lot of shitty first drafts before I get to high-quality work. Can you go get a massage while I get back to work?' And then perfectionism sort of releases its grip."

Amber stresses that this is a process she does with pen and paper and not out loud in public.

Rewriting the Narrative

We all have some idea of who we are and how we fit into the world, and we may even believe we have sole authorship of this narrative. But as much as we might hate to admit it, large chapters of the story were created by others before we even knew there was a story being written. Parents, teachers, friends, significant others, and bosses are just a few who, if they don't have entire chapters dedicated to them in your narrative, have at least scribbled significant notes in the margins. Sometimes the narrative even comes with irritating advertisements that fall on the floor every time you turn a page.

"I started my career in the advertising industry," says Amber, "and I remember one meeting where the CEO called us in and there was this new product for men to shine their shoes. And he's like, 'So, let's make men feel insecure about their shoes and then they'll buy the product.'

"So everything is around 'how do we tap into people's insecurities or sense of not enoughness in order to design products so that they buy them?'"

Becoming aware of an undesirable part of our narrative is an important first step in overwriting it. The second step is to question it and try to identify where it came from. Once we understand its origin story, we can decide if it's something that should remain in place or be torn out entirely and replaced with something better.

It might seem excruciating to sort through our narrative and deal with the emotions that will inevitably get stirred up in the process, but it's actually a shorter option than letting them linger and affect the entirety of our story.

As neuroanatomist and My Stroke of Insight author Jill Bolte Taylor discovered, it only takes 90 seconds to really feel the physiological impact of an emotion, examine it in the moment, and decide if it's something you need to keep reliving, or if it's something you can let go.

"It's like 90 seconds versus 10 years," says Amber. "It's not what happens and what we feel; it's the story we create about what we feel that prolongs."

Listen to this entire episode to learn more about ways to cultivate wonder, what it means to be a wonder junkie, the effect wonder can have on our physiology, how Amber's writing process probably differs from that of other authors you may recognize, how Reese's Peanut Butter Cups got smeared across the pages of my own narrative, and much more.

Resources from this episode:

Choose Wonder Over Worry: Move Beyond Fear and Doubt to Unlock Your Full Potential by Amber Rae

Amber's website

Amber at Instagram

Amber at Twitter

mindbodygreen

The Gifts of Imperfection: Let Go of Who You Think You're Supposed to Be and Embrace Who You Are by Brené Brown

Dan Siegel: Name it to Tame it

Contact by Carl Sagan

The Evangelist Behind Seth Godin's Speedy Publishing by Tim Donnelly, Inc.

The Genius Life 10: How to Become a World-Changing Innovator | Melissa Schilling

Quirky: The Remarkable Story of the Traits, Foibles, and Genius of Breakthrough Innovators Who Changed the World by Melissa A. Schilling

The Strategies That Helped Me Write 3 Books in 3 Years by Ryan Holiday

5 Life Lessons from the Book Journey by Amber Rae

This Yoga Nidra Routine Will Make You Feel Like You Got a Full Night's Sleep by Julie Hand, Bulletproof Blog

Headspace: Meditation and Mindfulness Made Simple

The Soul of Money: Transforming Your Relationship with Money and Life by Lynne Twist

The Life-Changing 90-Second Secret by Alex Myles, Elephant Journal

My Stroke of Insight: A Brain Scientist's Personal Journey by Jill Bolte Taylor

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 10: How to Become a World-Changing Innovator | Melissa Schilling

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The Genius Life 10: How to Become a World-Changing Innovator | Melissa Schilling

Melissa A. Schilling is the John Herzog Chair Professor of Management at New York University Stern School of Business, a world-renowned expert in innovation strategy, and author of Quirky: The Remarkable Story of the Traits, Foibles, and Genius of Breakthrough Innovators Who Changed the World.

What I discuss with Melissa in this episode:

  • The commonalities that unite world-shifting innovators like Steve Jobs, Elon Musk, Marie Curie, Thomas Edison, and Albert Einstein.

  • How we can embody these traits into our own lives to be more effective in achieving our goals—even if we don't consider ourselves to be "geniuses."

  • Why the list of innovators from Melissa's study isn't as diverse as she would have preferred.

  • The common innovator trait Thomas Edison did not possess (perhaps because he possessed twice as much of another trait).

  • The role of chronically elevated insulin and the ideology of Alzheimer's disease.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally. Check out what they can do for you here!

If I'd chosen to name this podcast The Einstein Life or my New York Times Best Seller Edison Foods, you'd have gotten the general idea: the names of these innovators have become synonymous with "genius." Our society elevates such geniuses to positions of high esteem when they help us see the world and its possibilities in a new light, which causes some of us to wonder: what makes world-changing innovators so different from the rest of us?

Quirky: The Remarkable Story of the Traits, Foibles, and Genius of Breakthrough Innovators Who Changed the World author Melissa A. Schilling joins us to discuss what sets innovators apart from most of us, what we can learn from their commonalities, how we can jump start our own capacity to innovate (even if we don't think of ourselves as "geniuses"), what an innovation strategy professor knows about the link between Alzheimer's disease and diabetes, and lots more.   

Not a Textbook Question

Management professor Melissa A. Schilling is so immersed in the science and data behind innovation strategy that she literally wrote the textbook for Strategic Management of Technological Innovation (now in its fifth edition). But an interesting thing happened back in 2010 when it became clear to the public that Steve Jobs, Apple's CEO and the company's public face of innovation, was in the late stages of a terminal illness. Melissa's students started asking her questions like: What's going to happen? If we lose Steve Jobs, will Apple not be innovative anymore? How much of that innovation comes from him as a man, and how much of it is myth? Can it be handed down? Can I learn it? Can I be innovative like that?

"I was really surprised," says Melissa," when I realized that we just didn't have the answer to that question. And in large part it's because our field is not well-structured to study people. I'm in a management school; we tend to study organizations and teams, but we don't tend to study individuals a lot. It's hard for us to publish that kind of work. And even in psychology, it's quite hard to do work on outliers—on creative geniuses—because it just sort of violates the standards of being able to do what we call rigorous research, meaning we want to run statistics on large samples. We want to have carefully controlled experiments. And you're not going to get Elon Musk or Steve Jobs into the laboratory to run an experiment on them!"

A Multiple Case Study for Innovation

Melissa found the questions surrounding the legacy of Steve Jobs—and what it means to be innovative—too fundamentally interesting to ignore. As an academic, she did what came naturally: she took a year-long sabbatical to study everything she could find on the subject of Steve Jobs until she felt like she "knew him as a person."

"And then at some point I recognized something really odd," says Melissa, "and that is that he had all these commonalities with this other inventor that I'd already written about, which is Dean Kamen...that's when I got the inspiration to do what we in my field would call a multiple case study research program, where you assemble a set of cases and you take yourself out of the case selection process as much as possible. You want something else—some kind of protocol—to select the cases. You don't want to select them yourself, because you might be creating bias somewhere. Then you do a full case development on each one—it's kind of like a biography on each one in this case—and you do what we call pairwise didactic comparison. So you take every pair and you find everything in common about them, and everything different about them. You look for themes and you try to discount the themes. You try to see which themes you can reject. And then what you're left with is pretty solid."

Addressing the Lack of Diversity

Aside from Steve Jobs and Dean Kamen, the other cases included for this study included Elon Musk, Nikola Tesla, Thomas Edison, Albert Einstein, Benjamin Franklin, and Marie Curie. If you've noticed a glaring lack of diversity in that lineup, you're not alone.

"One of the things that people have pushed back on a lot with this list is that fact that it's mostly male, and it's all what you think of as white—which is a bummer," says Melissa. "That's just history creating that. There's an incredible lack of access to science for people of color and even for women. A huge lack of access to science. When we studied Marie Curie's story, it's so inspirational and so sad at the same time. You can see how much she had to overcome. She had to overcome all of the same things that all of the other innovators had to overcome, and then so much more because she was a woman—and women just weren't welcomed into science."

When selecting from the cases available, Melissa had to make sure to draw from well-known innovators and inventors who had bountiful information about their lives available, like multiple biographies and first-hand contact materials such as direct correspondence. Unfortunately, this results in a fairly homogeneous candidate pool.

"If you...look at the last 300 years, throughout most of that period, women weren't even allowed in college," says Melissa. "Black people weren't allowed in college. Jews weren't allowed in a lot of colleges. So you had a huge access barrier there."

And while Marie Curie's father-in-law essentially raised her children while she single-mindedly focused on her scientific research and went on to become the only person to win a Nobel Prize in two different sciences, it was frowned upon by society at the time. Women were expected to take on the responsibility of caring for their family's children, so most simply didn't have the option to pursue the sciences; there's no telling how many generations of would-be innovators could have been included on the above list had they been given the choice.

"All the innovators, when you study them really closely, you realize that they...feel sort of separate from the crowd," says Melissa. "They don't belong. They don't feel like its rules apply to them. And one of the ways it becomes manifest is that they're a little bit...disagreeable. They're not going to go along to get along. They're not going to do what you expect them to do. They're going to challenge your rules and your assumptions, and they're going to stick with things even when you say it's not the right path. That's hugely important for being a breakthrough innovator, and I would say that women have always—and still to this day—pay a much higher penalty for being disagreeable."

The Unique Traits of Innovators

Over the course of her multiple case study, these are the traits Melissa found in common among most of these innovators:

Separateness. While Melissa was expecting to find diverse social networks that nurtured the minds of introverts, what she found instead was a tendency for these introverts to be loners to some degree and separate from the crowd. Nikola Tesla spent much of his childhood sick. Marie Curie battled depression. "There are various things that can lead to separateness," says Melissa. "But in all cases, what it did was made them feel like the norms that apply to you just don't apply to [them]..." Important to note: not the same as introversion.

Self-Efficacy. This can be defined as task-related self-confidence. "It's when you have a high faith in your ability to overcome obstacles to achieve your goals," says Melissa. Rather than being discouraged by failure, innovators will rally, double down, and try harder next time.

Idealism. An intrinsic motivator demonstrated by everyone on the list with the notable exception of Edison—who considered himself practical and decidedly not idealistic. "They were seeking some grand cause," says Melissa. "They were working for something much bigger than themselves. And because it was bigger than themselves, it didn't matter whether they made money at it. It didn't matter if they suffered. Sometimes they sacrificed their families and their health and certainly their leisure." Idealism also works as an ego defense against criticisms hurled at the innovator's work and rallies others to their cause.

Love of Work. If Edison didn't consider himself an idealist, he might proudly consider himself the figurehead of this trait. Hard work put Edison in a state of what Mihaly Csikszentmihalyi calls "flow," in which a pursuit is its own reward—providing the right levels of engagement and challenge to make the person enraptured by such a pursuit feel good. "You lose all sense of time, space, responsibility," says Melissa. "You are in the moment."

Self-Education. Not all innovators ever make it through the echelons of higher education—and in fact many reject its structure entirely. But they do possess an intellectual curiosity that drives them to understand the mysteries of the world on their own terms, and they tend to be voracious readers. "They were autodidacts," says Melissa. "They liked to learn and think about the stuff they wanted to learn and think about."

Listen to this full episode to learn more about what border collies can teach us about intrinsic motivation and flow, how nonexercise activity thermogenesis (NEAT) works (and how it may have been responsible for Edison's famous restlessness), why an innovator's separateness might work in the favor of his or her ideas remaining truly innovative, why many innovators prove to be mediocre students when held to the standards of someone else's educational pace, the resource seemingly least important to most innovators, how we can become innovative even if we don't consider ourselves outstanding in the IQ department, how the data collection for innovation strategy informed Melissa's paper about the correlation between Alzheimer's disease and diabetes, and much more.

Resources from this episode:

Quirky: The Remarkable Story of the Traits, Foibles, and Genius of Breakthrough Innovators Who Changed the World by Melissa A. Schilling

Melissa at Twitter

Melissa at NYU

Melissa's website

Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease by Melissa A. Schilling, Journal of Alzheimer's Disease

Strategic Management of Technological Innovation by Melissa A. Schilling

The Emotion Behind Invention by Dean Kamen at TEDMED 2009

Steve Jobs by Walter Isaacson

Code Name Ginger: The Story Behind Segway and Dean Kamen's Quest to Invent a New World by Steve Kemper

Elon Musk: Tesla, SpaceX, and the Quest for a Fantastic Future by Ashlee Vance

Tesla: Man Out of Time by Margaret Cheney

The Wizard of Menlo Park: How Thomas Alva Edison Invented the Modern World by Randall E. Stross

Albert Einstein: The Biography of a Genius Who Changed Science and World History by Adam Brown

Benjamin Franklin: An American Life by Walter Isaacson

Madame Curie: A Biography by Eve Curie and Vincent Sheean

Why Women Are Rarely Serial Innovators by Melissa Schilling, The Wall Street Journal

Mindset: The New Psychology of Success by Carol S. Dweck

Grit: The Power of Passion and Perseverance by Angela Duckworth

Intrinsic and Extrinsic Motivation: What's the Difference? by Sophia Bernazzani, HubSpot

Flow: The Psychology of Optimal Experience by Mihaly Csikszentmihalyi

Nonexercise Activity Thermogenesis (NEAT): Environment and Biology by James A. Levine, American Journal of Physiology-Endocrinology and Metabolism

Pramlintide

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

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The Genius Life 9: The Foods That Can Improve Your Smile | Steven Lin, DDS

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The Genius Life 9: The Foods That Can Improve Your Smile | Steven Lin, DDS

Steven Lin is a passionate health educator applying functional dentistry to help people achieve whole body health, a TEDx speaker, and author of The Dental Diet: The Surprising Link between Your Teeth, Real Food, and Life-Changing Natural Health.

What I discuss with Steven in this episode:

  • How an obscure tome first published in 1939 sparked Steven's interest in understanding ways to prevent oral afflictions with proper nutrition as a preference to the mainstream tendency to wait for problems to arise before fixing them.

  • Why are crooked teeth such a common sight today when they were relatively rare prior to the Industrial Revolution?

  • The value of fat soluble nutrients—like vitamin K2—seemingly absent from the modern supermarket.

  • How vitamin D deficiency can be passed from mothers to their children and the potential health problems that accompany this inheritance.

  • Teeth are living organs that can change throughout our adult years—for better or worse—depending on what we eat.

  • And much more!

This podcast is sponsored by my friends at Genuine Health, a Toronto-based supplement company committed to helping others achieve optimum health—naturally—with a line of fermented gut health and protein powders. Check out what they can do for you here!

If you're like most people, you probably think about your teeth as being the most steadfast part of your mouth's topography, fixed in place and composition from an early age—built to last, but destined to suffer inevitable degradation over time. Only the luckiest among us who make it to the village elder stage of life do so with a full set of chompers, due in no small part to daily diligence toward brushing and flossing.

But what if we regarded our teeth not as lifeless utensils, but the living organs they are? Then we could nurture them accordingly with the proper diet and care we afford to the rest of the body and enjoy their use well beyond the popularly misguided perception of a "natural" expiration date. The Dental Diet: The Surprising Link between Your Teeth, Real Food, and Life-Changing Natural Health author Steven Lin, DDS is an aptly described "interior designer for mouths" who shows us how we can treat our teeth with the respect they deserve by understanding the role they play in our overall health and providing them with everything they need to prosper.

A Modern Fixation on Fixing

Years of dental school taught Steven how to fix teeth. But it wasn't until, on a backpacking trip across Europe, he stumbled across a book called Nutrition and Physical Degeneration by Weston A. Price that he started to understand how a lot of the mouth ailments he was seeing as a practicing dentist were happening in the first place—not as inevitable degradation, but as a direct result of the modern diet's influence on dental health.

"Modern" is relative, considering this book was published for the first time in 1939. But it introduced ideas that Steven had never heard of in seven years of dental school, which made him initially skeptical.

"I picked it up, I looked at it, and I was like, 'Ah, this is a load of baloney! It's all outdated!' There were 15,000 photos in there, but they're black and white, so you kind of think in terms of our modern context we've moved past that. So I put the book in my backpack and I discounted it. I went away and then went back to practice and it kept bothering me. I kept thinking about it and eventually I picked it up again; I realized that I didn't understand it.

"What he was talking about—the development of jaws and crooked teeth and why kids need braces today, and tooth decay—it is all a problem with food nutrient deficiencies. They're a screaming message from our body that we're not eating the right things. So that led me down the path of thinking anthropologically about the mouth and the context of dental disease and digging into the science of how we understand the mouth and the oral cavity as a model for whole-body health."

Forbidden Knowledge Vindicated

Steven's book is the result of his own 21st century observations and explorations sparked by ideas presented in what may as well have been a tome of forbidden knowledge from the better side of a century ago, randomly accessed on a personal voyage of self-discovery. Why this information took such a roundabout way to reach a greater audience instead of being taught in dental school for the past few generations is anybody's guess. But research conducted today is constantly confirming what Weston Price tried to tell us nearly 80 years ago.

Even the importance of vitamins K and K2—especially to oral health—is only now being understood, though Weston Price and a few of his contemporaries had already speculated on their efficacy in providing protection from tooth decay and chronic disease by the early 20th century.

And just as it took scientists until the mid-'90s to realize that our brains are constantly changing and regenerating rather than being fixed by a certain age, Steven is trying to get the word out that our teeth are similarly in a constant state of flux dependent on how we choose to take care of ourselves.

Every Bite You Take

"Our bodies are listening to every bite that we take, nutritionally," says Steven. "The teeth, I think, are one of the first signs of how we're eating the wrong or the right foods. Teeth are living organs; we've known this. We know that teeth have a blood supply, they have a nerve supply. We're taught this in dental school, but we're not taught how to feed them so they actually can function properly.

"We have living cells inside our teeth called odontoblasts that are waiting for a set of nutrients called the fat soluble vitamins—of which vitamin K2 is one; they're activated especially by vitamin A and vitamin D—so without those nutrients, you don't activate these defender cells. What they do is they release an immune reaction inside your teeth to potential harmful bacteria."

Listen to this full episode to learn more about what Weston's studies found to be the greatest differentiator between modern and traditional diets, why braces are ubiquitous among developing children today (while crooked teeth were a rarity until recent history), how vitamin D deficiency is passed from mother to child and what traditional diets did to prevent this, the foods we should be eating for optimal dental health, the foods we should be avoiding, the cholesterol connection to dental health, what the Fibonacci Sequence tells us about the human smile, mouth breathing versus nose breathing, why some of us grind our teeth when we sleep, why regular use of mouthwash could be hazardous to your health, and much more.

Resources from this episode:

The Dental Diet: The Surprising Link between Your Teeth, Real Food, and Life-Changing Natural Health by Steven Lin

Steven's website

Steven at Instagram

Steven at Twitter

The Power of a Smile with Steven Lin at TEDx Macquarie University

There's an original version of Nutrition and Physical Degeneration by Weston A. Price posted online courtesy of Project Gutenberg Australia for free here, or a more modern paperback 8th edition can be found on Amazon here.

Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life by Kate Rheaume-Bleue

A Decade Of Discovery Yields a Shock About the Brain by Sandra Blakeslee, The New York Times

Odontoblasts: Specialized Hard-Tissue-Forming Cells in the Dentin-Pulp Complex by Nobuyuki Kawashima and Takashi Okiji, Congenital Anomalies

Vitamins Are Important For Your Teeth with Dr. Steven Lin, Hay House Australia

Fat soluble vitamins mentioned by Steven

Are You Ready to Eat Your Natto? by Richard Schiffman, The New York Times

Occlusal Variation in a Rural Kentucky Community by Robert S. Corruccinni and L.Darrell Whitley, American Journal of Orthodontics

Your Sweet Tooth, the Oral Microbiome, and Tooth Decay by Steven Lin, I Quit Sugar

Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan M.D.

The Truth about Cholesterol with Mike Mutzel and Max Lugavere (Full interview here.)

Taking a Statin Drug? Here Are 3 Nutrients That May Be Depleted by Colin O'Brien, ND

The Fibonacci Sequence: Nature's Code with Hank Green, SciShow

Sleep Strips by SomniFix (to promote nose breathing)

Is Mouth Breathing Bad for Your Health? by Steven Lin

Twice-Daily Mouthwash Use Could Increase Risk of Type 2 Diabetes by Jack Woodfield, Diabetes.co.uk

How Your Gut Microbiome Links to a Healthy Mouth by Steven Lin

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

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The Genius Life 8: How Fasting Can Rebuild Your Immune System | Valter Longo, PhD

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The Genius Life 8: How Fasting Can Rebuild Your Immune System | Valter Longo, PhD

Valter Longo is a professor of gerontology and biological science at USC and Director of the USC Longevity Institute. He is one of the foremost researchers studying fasting—developing what he calls the Fasting Mimicking Diet—and is the author of The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight.

What I discuss with Valter in this episode:

  • What Valter's mentor, the late Roy Walford, learned about the benefits—and drawbacks—of near-starvation during his two years sealed off from the rest of the world in Biosphere 2.

  • How a carefully controlled cycle of fasting and refeeding has proven effective in targeting cancer while minimizing collateral damage to normal cells during chemotherapy.

  • The regenerative effects of fasting and refeeding on the immune system, and the strides being made toward potentially miraculous MS and diabetes treatments.

  • How the Fasting Mimicking Diet works and how often it should be observed.

  • What Valter thinks of intermittent fasting and the true purpose of ketones.

  • And much more!

While fasting, in its many forms, has been used around the world over the centuries for everything from religious observance to political protest, current research is proving it to be effective in promoting a seemingly countless number of health benefits under properly controlled circumstances.

Spearheading some of the most groundbreaking research in fasting is USC professor Dr. Valter Longo, PhD, author of The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight. In addition to metabolism boost and weight loss long associated with fasting, Valter's research suggests that fasting can “reset” the immune system to potentially treat conditions like multiple sclerosis and type one diabetes, and even significantly increase longevity.

From Song to Science

As a music student in Texas, Valter Longo didn't want to direct the college marching band; he wanted to rock. But there were vexing lifelong questions that even rock and roll couldn't answer.

"I was in the room when my grandfather died," says Valter. "I was five years old or something like that. Probably that was in my head very clearly. Like 9/11, you have those events that you might not think about all the time, but they're in your head. I think that maybe I always wanted to figure out 'Why did he die when I was so young?' And I think he also died [40 or 50 years] before he had to. He only had a hernia, and because it was left untreated, it ended up killing him way before his time."

On the other hand, his neighbor, who lived a similar lifestyle and ate a similar diet, lived to be 110.

So Valter decided to pursue science perhaps as a way to understand the mechanics of mortality and what might be done to help people enjoy a longer, healthier life on the planet.

Starvation Lessons from a Biosphere 2 Pioneer

One of Valter's mentors was a gerontologist named Roy Walford, who spent two years with seven other people sealed off from the rest of the world in the self-contained Biosphere 2 just outside Tucson in the early '90s. While there, the group soon discovered they were unable to grow enough food to sustain a normal diet, so Roy put them on a severely calorie-restricted diet that would keep them from starving—but just barely.

Years later, Roy's 2004 Los Angeles Times obituary would recount:

They didn't exactly flourish, but they did get healthier. Men lost nearly 20% of their body weight and women about 10%. Their blood pressure, blood sugar, cholesterol and triglyceride levels all fell by at least 20% to extremely healthy levels. The team members also exhibited an increased capacity to fight off illnesses, such as colds and flu.

Valter was impressed with the possibilities his mentor's experiment presented, but recognized its imperfections and looked toward ways it might be improved.

"I thought, well, I need to go back to bacteria and yeast and simple organisms to figure out the fundamentals," says Valter. "And that was the right track."

This course of experimentation allowed Valter and his team to identify key genes that regulate longevity, and they were surprised to find that introducing the organisms to starvation counterintuitively shielded them from damage and allowed them to lead longer lives.

Getting the Drop on Cancer and Resetting the Immune System

Taking what they learned from their yeast studies, Valter and his colleagues scaled up to mice and discovered that not only would starvation before chemotherapy greatly protect the normal cells from damage, but it would simultaneously make cancer cells more susceptible to the treatment.

"From there we moved to many more studies in mice, and then eventually humans," says Valter.

Further trials found that observing cycles of fasting and refeeding would prompt stem cells in compromised immune systems to pump out new white blood cells and recycle damaged, old, and inefficient cells.

Fasting Mimicking Diet and Embryonic-Like Rebirth

Further studies still have determined that Valter's Fasting Mimicking Diet, as featured in his new book, shows promise in fighting the ravages of multiple sclerosis (MS) as well as rebuilding the diabetic pancreas. As in earlier tests, a cycle of fasting and feeding triggers a regenerative process that promotes vastly marked improvements.

"I think that the most striking example is our type 1 diabetes paper where we show in the pancreas that you can almost completely destroy the beta cells of the pancreas, and then you start the cycles of fasting mimicking dietary feeding and you see the insulin generation going back to normal and the glucose coming back to almost normal levels. So it's very powerful in activating what I call an embryonic-like program. If you look at the genes that are expressed, they're very similar to the genes that you see expressed in fetal development."

Listen to this full episode to learn more about why Valter believes the term "intermittent fasting" is commonly misused to the point of being meaningless, what really qualifies as fasting to Valter, how he regards ketones, how the average person should approach fasting and the Fasting Mimicking Diet, where the Longevity Diet fits in, weighing the efficacy of a diet to the average person's ability to stick to it over time, two debunked nutrition notions that commonly move people off the path to health, the cardiovascular risks of skipping breakfast, and lots more.

Resources from this episode:

The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight by Valter Longo

Valter at USC

Valter at Facebook

Valter Longo Foundation

USC Longevity Institute

The Fasting Mimicking Diet

Roy Walford, 79; Eccentric UCLA Scientist Touted Food Restriction by Thomas H. Maugh II, The Los Angeles Times

Biosphere 2

Dietary Restriction, Growth Factors and Aging: From Yeast to Humans by Valter D. Longo et al., Science

Starvation-dependent Differential Stress Resistance Protects Normal but Not Cancer Cells Against High-dose Chemotherapy by Valter D. Longo et al., Proceedings of the National Academy of Sciences of the United States of America

Fasting for Three Days Can Regenerate Entire Immune System, Study Finds by Sarah Knapton, The Telegraph

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms by Valter D. Longo et al., Cell Report

Fasting-mimicking Diet Shows Promise Against MS by Catharine Paddock, Medical News Today

Fasting-Mimicking Diet Promotes Ngn3-Driven Beta-Cell Regeneration to Reverse Diabetes by Valter D. Longo et al., Cell

Fasting Diet 'Regenerates Diabetic Pancreas'  by James Gallagher, BBC News

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 7: Why You Probably Need to Eat More Salt | James DiNicolantonio, PharmD

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The Genius Life 7: Why You Probably Need to Eat More Salt | James DiNicolantonio, PharmD

James DiNicolantonio is a doctor of pharmacy, a cardiovascular research scientist at Saint Luke's Mid America Heart Institute, the associate editor of British Medical Journal's (BMJ) Open Heart, and author of The Salt Fix: Why the Experts Got It All Wrong—and How Eating More Might Save Your Life.

What I discuss with James in this episode:

  • What are the symptoms of salt deficiency?

  • Who should be on a salt-restricted diet?

  • Why might someone on a ketogenic diet notice an increased craving for salt?

  • With so many options now available, what's the healthiest salt you can buy?

  • How much is too much salt?

  • And much more!

Salt has been demonized and blamed for many of the Western world's medical ailments—from hypertension to heart failure—existing in such ubiquitous abundance that, we've long been told, we could all afford to do with less of it. But what if, like an urban legend that captivates popular imagination without any basis in fact, the reality is actually the opposite of what we've been led to believe? What if, as a society, we're not getting enough salt?

In this episode, we get to pick the brain of a cardiovascular research scientist and doctor of pharmacy who some might consider a devil's advocate on the topic of salt: Dr. James DiNicolantonio, author of The Salt Fix: Why the Experts Got It All Wrong—and How Eating More Might Save Your Life. He'll explain how salt become demonized in recent history, why too little sodium is far worse for us than too much, symptoms of salt deficiency, and a whole lot more.

Salt: How Low Can You Go?

As a research scientist for Saint Luke's Mid America Heart Institute in Kansas City, James has published more than 200 papers on nutrition and how it relates to cardiovascular health. When he was a community pharmacist, he noticed an influx of patients who complained of dizziness, fatigue, exercise intolerance, and high heart rates.

What they had in common was high blood pressure, a doctor-prescribed low-salt diet, and overwhelming sadness from eating exclusively flavorless food.

As a high school athlete, James knew his physical performance suffered if he didn't ingest enough salt, so he recommended these patients revisit the doctor to get their sodium levels checked. Of no surprise to James, it turned out they were low.

And so began James' quest to discover if, rather than being a society overfed on salt, we might in fact be a society suffering from an epidemic of salt depletion.

The Demonization of an Unappreciated Nutrient

"You talk to anyone back in the '50s, '60s, '70s, it was really well known in athletic performance that you take a salt tablet," says James. "After we demonized salt [in 1977's Dietary Goals for the American People], virtually no one that I've talked to in the athletic world really understands the benefits of salt, and that really was something very eye opening in my research."

According to James, this demonization came about from an oversimplified test.

"Basically, just like with dietary fat—how we oversimplify the LDL cholesterol leading to heart disease type of pathway—we oversimplified it with salt. We took one surrogate marker blood pressure and we fell at the feet of it...it was a very simple hypothesis that if you consume more salt, you are going to raise your sodium levels, you're going to activate thirst, you're going to drink more water to dilute those higher sodium levels, so that's going to raise blood volume and lead to high blood pressure. We based these low salt guidelines on complete hypothesis."

A hypothesis that James believes causes more damage than taking the exact opposite action of the one prescribed.

"If we don't get enough salt, so many other harms outweigh any type of potential benefit and in the book I show that even if you get a reduction in blood pressure when you cut your salt intake, you're just volume depleting yourself and raising your heart rate."

Hyponatraemia and Cognitive Impairment

Sodium is crucial to many human biological functions, not the least of which is the transport and absorption of vitamin C into the brain, our bones, and the intestinal tract. Hyponatremia—caused by abnormally low sodium levels in the blood—can result in a number of dangerous disorders on a cellular level. Not surprisingly, cognitive impairment is just one of the symptoms observed from this type of sodium deficiency as vitamin C is instrumental in the synthesis of neurotransmitters.

"There's actually studies showing that if you induce low sodium levels in animals, you can actually cause cognitive impairment and memory impairment," says James. "Literally, they can't follow through the maze as well..."

Listen to this full episode to learn more about the difficulties in gauging ideal—but ever-fluctuating—blood sodium levels, how greater quantities of salt counterintuitively ensure we remain hydrated, how overtraining syndrome and headaches during a workout are tied to salt deficiency of the tissues, what a Blood Urea Nitrogen (BUN) marker can tell you about your sodium levels, if there are people who actually shouldn't be taking in more salt, how caffeine affects our sodium levels, why James believes people with type two diabetes should be eating more salt rather than the recommended less, why people observing a ketogenic diet especially crave salt, the salt James himself uses, and lots more.

Resources from this episode:

The Salt Fix: Why the Experts Got It All Wrong—and How Eating More Might Save Your Life by Dr. James DiNicolantonio

The Genius Life 32: Fats That Heal, Fats That Kill | James DiNicolantonio, PharmD

James' website

James at Twitter

James at Facebook

James at Instagram

History of Dietary Guidance Development in the United States and the Dietary Guidelines for Americans

Association between Antidepressant Drug Use and Hyponatraemia: A Case-Control Study by Kris L.L. Movig et al., British Journal of Clinical Pharmacology

Association between Dietary Sodium Intake and Cognitive Function in Older Adults by Toni M. Rush et al., The Journal of Nutrition Health and Aging

Hyponatremia: Symptoms and Causes, The Mayo Clinic

Blood Urea Nitrogen (BUN): What It Is and Why Is Yours High (or Low) by Jade Teta, Metabolic Effect

A Low-Salt Diet May Be Bad for the Heart by Nicholas Bakalar, The New York Times

Salt: The Prize Jewel Of Keto by Anita Aldridge, Ketovangelist

Ancient Lakes Magnesium-Infused Salt

Redmond Real Salt

Could So-Called 'Healthy' Vegetable And Seed Oils Be Making Us Fat And Sick? by James J. DiNicolantonio and Sean C. Lucan, Forbes

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

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The Genius Life 6: The Crazy Link Between Diabetes and Alzheimer's | Amy Berger

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The Genius Life 6: The Crazy Link Between Diabetes and Alzheimer's | Amy Berger

Amy Berger is a certified nutrition specialist and nutritional therapy practitioner who holds a master's degree in human nutrition from the University of Bridgeport, and is the author of The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer’s Disease, Memory Loss, and Cognitive Decline.

What I discuss with Amy in this episode:

  • Why the prevailing hypothesis behind Alzheimer's disease doesn't seem to add up—and what Amy and I believe is a more plausible explanation.

  • What a ketogenic diet in tandem with exogenous ketones can do to fight back against the advance of Alzheimer's disease.

  • How a caregiver can help a patient with dementia who is resistant to a change in diet.

  • What young people can do right now to proactively reduce the chances of picking up Alzheimer's disease later in life.

  • Supplements Amy recommends for targeted brain health.

  • And much more!

While there are multiple hypotheses as to why Alzheimer's disease develops, the prevailing wisdom of the past few decades has aligned with the amyloid hypothesis—that Alzheimer's is caused by plaque buildup in the brain. Unfortunately, amyloid hypothesis-directed drug trials for Alzheimer's disease treatment have a 99.6 percent fail rate.

On the other hand, there's a growing number of both researchers and clinicians who believe that Alzheimer's disease is a form of diabetes of the brain that is metabolic in origin. This is the camp where I find myself, and I'm in good company with Amy Berger, author of The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer’s Disease, Memory Loss, and Cognitive Decline.

A Late Start

Amy's journey into nutrition—and specifically how it relates to Alzheimer's disease—started later in life.

"Like so many people out there, I was overweight—despite doing what I believed were all the right things," says Amy. "I ate a low-fat diet, lots of good, whole grains, whole wheat bread, cereals, skim milk. I exercised a lot—I was not afraid of a hard workout. And yet I was still carrying all this extra weight. At the time I was young enough that I didn't really have any health problems, but I could not understand why I could not lose weight no matter what I did.

"There were people around me, friends and family who ate far worse than I did—wouldn't know a barbell from a jingle bell—and they looked better than I did!"

But around 1999, Amy came across an early copy of Dr. Atkins' New Diet Revolution and it changed everything.

"Having realized that I could actually lose weight and be healthy—and feel great—eating things like steak and blue cheese and coconut oil and butter and fatty pork chops and bacon—you name it—how could I not want to share that with other people who were struggling, too?" says Amy.

This prompted Amy to change careers and return to school to study nutrition. Now she specializes in low-carb, ketogenic, and paleo-style diets not only to help others with weight loss, but also for managing blood sugar, hormone imbalances, and other medical conditions improved by a change in nutrition.

"Just Because We Don't Know Everything Doesn't Mean We Don't Know Something."

Like Dr. Atkins himself, Amy knows what it's like to hold opinions that run counter to those promoted by the mainstream—and how maddening it can be when abundant evidence supports what she finds to be obvious. One of these obvious positions is the connection between Alzheimer's disease, glucose, and insulin, which she examined in great detail in the course of writing her thesis.

"When I started looking for scientific papers, I was blown away by what I found. It is everywhere in the scientific literature. Alzheimer's disease is regularly referred to as 'type 3 diabetes,' 'diabetes of the brain,' sometimes they call it 'brain insulin resistance.' If people out there have heard of metabolic syndrome, they also call Alzheimer's 'metabolic cognitive syndrome.' I mean, this is everywhere! How did I never hear of it? As someone who's actually really interested in low-carb and interested in insulin issues and ketones, how did I not come across this before a book? Not hearing it from a doctor, not hearing it from a specialist, but hearing it from a journalist [Gary Taubes] who wrote a book [Good Calories, Bad Calories] about low-carbohydrate diets.

"I wrote the thesis, did the research, and having learned what I learned, I couldn't imagine keeping it to myself...it's overwhelming to me that we're being told there's nothing you can do about Alzheimer's; you just have to accept your fate and prepare for the worst. Granted, there's a lot of unanswered questions. There are a lot of things we don't know. But just because we don't know everything doesn't mean we don't know something. It doesn't mean we have no actionable information right now."

Fueling the Brain with Ketones

Neurons in patients afflicted with Alzheimer's disease show a reduced ability to derive fuel from glucose—they starve to death and atrophy, which can be detected in scans as a loss of matter in the brain.

"The synapses, the connect neurons go away; communication between these neurons breaks down," says Amy. "The obvious result is memory loss, behavioral changes, and personality changes. The bottom line: whatever else is going on in Alzheimer's, in my opinion, the number one thing we can do is nourish these starving brain cells. And there's a lot of other things we need to do, but to me, that's step one."

Amy believes the best way to nourish these starving brain cells is by observing the ketogenic diet, which provides ketones as a fuel alternative to glucose. Additionally, supplementing with exogenous ketones can help further improve cognitive function—but shouldn't be seen as a substitute for the diet.

"Exogenous ketones are a great short-term way to manage symptoms," says Amy. "They do improve cognitive function, but they do nothing to actually reverse or slow the disease process. And I think a ketogenic diet can."

In cases where a patient is resistant to a change in diet (particularly if advanced dementia is present), Amy recommends caregivers introduce MCT oil or coconut oil as good sources of fat that readily convert to ketones in the body.

Listen to this full episode to learn more about the benefits of low-carb and ketogenic diets for young people proactively looking to reduce their chances of picking up Alzheimer's disease later in life (and positive cognitive effects they may even experience right away), metabolic flexibility, the diet Amy recommends to someone seeking to optimize cognitive performance, supplements Amy recommends for targeted brain health, nutrition recommendations for ApoE4 carriers, Amy's take on HDL and LDL cholesterol levels, and lots more.  

Resources from this episode:

The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer’s Disease, Memory Loss, and Cognitive Decline by Amy Berger

Tuit Nutrition

Amy at Twitter

Is the Alzheimer's "Amyloid Hypothesis" Wrong? by Sarah Zhang, The Atlantic

Dr. Atkins' New Diet Revolution by Robert C. Atkins

PubMed

Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes

Alzheimer's Disease Is Type 3 Diabetes—Evidence Reviewed by Suzanne M. de la Monte et al., Journal of Diabetes Science and Technology

Diabetes of the Brain by Alissa Sauer, Alzheimers.net

Demonstrated Brain Insulin Resistance in Alzheimer's Disease Patients Is Associated with IGF-1 Resistance, IRS-1 Dysregulation, and Cognitive Decline by Konrad Talbot et al., The Journal of Clinical Investigation

Metabolic-Cognitive Syndrome: A Cross-Talk between Metabolic Syndrome and Alzheimer's Disease by Vincenza Frisardi et al., Ageing Research Reviews

Are Exogenous Ketones Right for You? by Marty Kendall, Optimising Nutrition

What Is Metabolic Flexibility, and Why Is It Important? J. Stanton, Gnolls.org

Supplements Amy mentions:

The Empowering Neurologist—David Perlmutter, MD, and Max Lugavere

Scientists Reveal Why People with the ApoE4 Gene Are More Susceptible to Alzheimer's Disease, Salk Institute

Dr. Gundry's Protocol

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!

 

 

 

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The Genius Life 5: Blueberries and Ketosis For A Better Brain | Robert Krikorian, PhD

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The Genius Life 5: Blueberries and Ketosis For A Better Brain | Robert Krikorian, PhD

Robert Krikorian is a professor in the Department of Psychiatry and Behavioral Neuroscience and the director of the Cognitive Aging Program at the University of Cincinnati Academic Health Center. He is one of the lead researchers exploring ketogenic diet as an intervention for people with cognitive impairment, and on the impact of anthocyanins (antioxidants found in blueberries and other pigmented fruits and vegetables) on cognitive aging. 

What I discuss with Robert in this episode:

  • How an aspiring psychotherapist with no family history of neurodegeneration became one of the leading researchers in dietary methods of fighting cognitive impairment and aging.

  • What Robert believes is the most potent factor in influencing our health and longevity.

  • What happened to a group with mild cognitive impairment (MCI) who observed the low-carb, high-fat ketogenic diet.

  • The implications of these findings for young people seeking to entirely prevent cognitive impairment with the benefit of early awareness.

  • The impact of the humble blueberry (and related pigmented fruits and vegetables) on cognitive aging.

  • And much more!

The cost of treatment for neurodegenerative diseases like Alzheimer's and Parkinson's can be high, and the emotional toll on those affected—from the afflicted to those caring for the afflicted—is even higher. But what if non-pharmaceutical interventions during or before the early stages could stall or halt their progress entirely? In this case, an ounce of prevention would surely be worth, at the very least, a pound of cure. 

University of Cincinnati professor Robert Krikorian, PhD joins us to discuss his research into the positive effects of the low-carb, high-fat ketogenic diet on patients with mild cognitive impairment (MCI) and how anthocyanins (antioxidants found in blueberries and other pigmented fruits and vegetables) may stall the effects of cognitive aging.

Treatment with the Tools at Hand

With scholarly interests ranging from astronomy to philosophy and a career path that initially seemed destined toward psychotherapy, it's perhaps surprising Dr. Robert Krikorian became one of the leading researchers in nutritional methods—namely the ketogenic diet and use of anthocyanin-rich foods like blueberries—to forestall neurodegeneration.

"I have a clinic and we see patients from age seven through old age. I would guess about eight years ago, maybe 10 years ago, we started to see more people who are middle-aged and older with age-related memory changes. The typical patient was sort of dysthymic—had a little bit of depression and increased anxiety—and starting to have some cognitive changes. I noticed some things about them in terms of simple observations about the other health conditions they had, like typically hypertension and sometimes type two diabetes. They seemed to be overweight as a group, and it just occurred to me that this was going to become a major issue in the population as a whole."

While he has no family history of neurodegeneration, Robert recognized the societal implications of this growing segment of the populace and began to examine its causes and ways it might be countered. But there were limitations to how he could proceed.

"I'm not a physician; I'm a PhD, and so I don't have access to medications as treatment tools," says Robert. "I was focused on nutrition, stress control, and exercise...with those tools, I thought that diet or nutrition was the most potent way to approach this, and I really felt strongly that prevention was much prefered relative to cure."

The Ketogenic Diet vs. Mild Cognitive Impairment (MCI) 

The low-carb, high-fat ketogenic diet has been used to treat a number of ailments—from epilepsy to diabetes to obesity—for more than a century. In a nutshell, it creates the conditions for your body to burn fat, rather than sugar, as a fuel. It improves triglyceride and cholesterol levels, lowers blood sugar levels, and it optimizes insulin to name a few of its proven benefits. 

During a six-week intervention (preceded by a three-week pre-pilot phase), patients exhibiting mild cognitive impairment (MCI)—a group at risk for later development of Alzheimer's or other forms of dementia—were instructed to observe a low-carb, high-fat ketogenic diet. And while weight loss typical to such a diet predictably occured, a significant improvement in cognition was also noted.

"Many people over the age of 55-60 in our culture are hyperinsulinemic," says Robert. "They're not yet diabetic, but they're sort of on that path, generally speaking. And they have elevated levels of insulin, but the glucose is not high enough yet to meet standards for treatment as diabetics. But I think damage is still being done in that phase, and that phase can be very long...but in any case, we lowered insulin into the reference range and it was just at the upper limit of the reference range...so I thought part of it was the correction of hyperinsulinemia, but I thought that there was another component which might have been an energetic component—that is, we were improving mitochondrial energy production in the brain."

A smaller extension study under similar conditions included brain imaging; cognition improvements were once again verified, with significant increase in neurochemicals like myo-inositol and trends for increases in N-acetylaspartate, creatine, and phosphocreatine after six weeks on the ketogenic regimen.   

This is Your Brain on Blueberries

Robert was particularly inspired by a 1999 study done by James A. Joseph of Tufts University in which middle-aged rats given strawberry, spinach, and blueberry supplements were able to perform mental tasks as well as rats belonging to a younger group. Its conclusion: These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

"Blueberries, in particular, contain five of the six major anthocyanins [antioxidants found in blueberries and many other purple-hued fruits and vegetables]...they seem to have a lot of benefits for us with respect to the antioxidant and anti-inflammatory benefits, but also they do some of the things we talked about with ketone metabolism."

Robert mentions that, additionally, they seem to improve glucose disposal independent of the level of insulin that the body produces.

Another curious observation is that the metabolic processes triggered by the introduction of anthocyanins seem to linger long after the anthocyanins themselves have been digested.

"The question becomes: is it the metabolic process? Is it what the organism is doing with the anthocyanins that's switching on the signals and producing the benefit, or is it the acute consumption of the parent—the food form compounds? The data we have from these two studies...suggest that it's the acute consumption. It's the parent compounds that the cognitive benefits seem to be associated with."

Listen to this full episode to learn more about the details behind how Robert believes (and research suggests) ketosis facilitates cognitive improvement, how young people might use this information to prevent cognitive impairment early on, Robert's take on the use of MCT oil and exogenous ketones, Robert's aspirations to compare the benefits of blueberry supplementation against ketogenic diet for cognitive improvement, what Robert's own diet looks like, and lots more. 

Resources from this episode:

Robert Krikorian at University of Cincinnati's Department of Psychiatry and Behavioral Neuroscience

Cognitive Aging Program , University of Cincinnati 

Dietary Ketosis Enhances Memory in Mild Cognitive Impairment by Robert Krikorian et al., Neurobiology of Aging

What Is Mild Cognitive Impairment? National Institute on Aging

What is the Ketogenic Diet? A Comprehensive Beginner's Guide, ruled.me

Enhanced Cerebral Bioenergetics with Dietary Ketosis in Mild Cognitive Impairment by Robert Krikorian et al., Nutrition and Aging

Scientists Reveal Why People with the ApoE4 Gene Are More Susceptible to Alzheimer's Disease, Salk Institute

What is Myo-inositol? Examine.com

What is N-acetylaspartate? N-acetylaspartate.com

What is Creatine? Examine.com

What is Autophagy? by Ananya Mandal, News-Medical.Net

A Ketogenic Diet Reduces Amyloid Beta 40 and 42 in a Mouse Model of Alzheimer's Disease by Ingrid Van der Auwera et al., Nutrition & Metabolism

Exercise Promotes the Expression of Brain Derived Neurotrophic Factor (BDNF) through the Action of the Ketone Body Beta-Hydroxybutyrate by Sama F Sleiman et al., eLife

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease by Stephen Cunnane, Frontiers in Molecular Neuroscience

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation by James A. Joseph et al., The Journal of Neuroscience

What Are Anthocyanins and Why Are Purple Foods So Healthy? by Sarah Lienard, BBC

Neuroprotective Effect of Anthocyanins on Acetylcholinesterase Activity and Attenuation of Scopolamine-Induced Amnesia in Rats by JM Gutierres et al., International Journal of Developmental Neuroscience

Blueberry Extract Enhances Survival of Intraocular Hippocampal Transplants by L. Willis et al., Cell Transplant

Impact of Diet on Adult Hippocampal Neurogenesis by Doris Stangl and Sandrine Thuret, Genes & Nutrition

Blueberry Supplementation Improves Memory in Older Adults by Robert Krikorian et al., Journal of Agricultural and Food Chemistry

Cognitive Improving Effects by Highbush Blueberry (Vaccinium Crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model by SM Hong et al., Journal of Agricultural and Food Chemistry

ORAC Values: Antioxidant Values of Foods & Beverages, Superfoodly

Nutritional Dangers of Acid Reflux Medications by Kimmi Le, lifeextension.com

Genius Foods: Become Smarter, Happier, and More Productive While Protecting Your Brain for Life by Max Lugavere and Paul Grewal M.D.

Join my mailing list and get access to the free PDF of 11 supplements that can help boost your brain function!
 

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